Abstract
Twenty-one hydrazides were synthesized by treating different esters with hydrazine hydrate. Substituted hydrazides were obtained by treating hydrazides with alkyl/aryl/acyl halides. Some of these compounds exhibit potential in vitro leishmanicidal activity. The structures of all the synthesized compounds were confirmed by spectroscopic analysis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkylation
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Animals
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Antiprotozoal Agents / chemical synthesis*
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Antiprotozoal Agents / pharmacology*
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Hydrazines / chemical synthesis*
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Hydrazines / pharmacology*
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Indicators and Reagents
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Leishmania major / drug effects*
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Magnetic Resonance Spectroscopy
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Solvents
Substances
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Antiprotozoal Agents
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Hydrazines
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Indicators and Reagents
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Solvents
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hydrazine