Synthesis and antitumor activity of cyclopentadienyltitanium substituted polyoxotungstate [CoW11O39(CpTi)]7- (Cp=eta5-C5H5)

J Inorg Biochem. 2003 Mar 1;94(3):279-84. doi: 10.1016/s0162-0134(02)00631-1.

Abstract

A novel polyoxotungstate [CoW(11)O(39)(CpTi)](7-) (Cp=eta(5)-C(5)H(5)) has been prepared. This complex exhibits the highest antitumor activity in vitro among the cyclopentadienyltitanium substituted polyoxometalates investigated and has a remarkable inhibitory action on three types of human cancer cells, SSMC-7721, HL-60 and HLC, in vivo.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • DNA / chemistry
  • DNA / drug effects
  • Drug Screening Assays, Antitumor
  • Electrochemistry
  • Humans
  • Nucleic Acid Conformation / drug effects
  • Organometallic Compounds / chemical synthesis*
  • Organometallic Compounds / chemistry
  • Organometallic Compounds / pharmacology*
  • Oxidation-Reduction
  • Spectrum Analysis
  • Titanium / chemistry
  • Tumor Cells, Cultured
  • Tungsten Compounds / chemical synthesis
  • Tungsten Compounds / chemistry
  • Tungsten Compounds / pharmacology

Substances

  • Antineoplastic Agents
  • Organometallic Compounds
  • Tungsten Compounds
  • DNA
  • Titanium