A 2,3-butanedione protected chiral glycine equivalent--a new building block for the stereoselective synthesis of enantiopure N-protected alpha-amino acids

Chem Commun (Camb). 2003 Feb 21:(4):468-9. doi: 10.1039/b210673f.

Abstract

A new chiral glycine equivalent 7 has been synthesised from glycidol using a chiral memory protocol, and its use in the synthesis of N-Z protected alpha-amino acids was demonstrated in a series of diasteroselective lithium enolate alkylation reactions and subsequent acid hydrolyses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkylation
  • Amino Acids / chemical synthesis*
  • Diacetyl / chemistry
  • Hydrolysis
  • Lithium
  • Stereoisomerism

Substances

  • Amino Acids
  • Lithium
  • Diacetyl