Taxanes in the treatment of advanced (stage III and IV) non-small cell lung cancer (NSCLC): recent developments

Cancer Invest. 2003;21(1):87-104. doi: 10.1081/cnv-120005919.

Abstract

Taxanes, paclitaxel, and docetaxel have become the cornerstone of both first-line and second-line chemotherapy for advanced non-small cell lung cancer (NSCLC). Recently, several pivotal phase III randomized trials have been published. These studies and phase II trials will be discussed. Additionally, studies utilizing a taxane and radiation therapy for resectable and locally advanced NSCLC will be outlined. The article will end with a discussion on newer strategies being currently explored to improve survival in advanced NSCLC.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Angiogenesis Inhibitors / therapeutic use
  • Antineoplastic Agents, Phytogenic / administration & dosage
  • Antineoplastic Agents, Phytogenic / therapeutic use*
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Carcinoma, Non-Small-Cell Lung / drug therapy*
  • Carcinoma, Non-Small-Cell Lung / mortality
  • Carcinoma, Non-Small-Cell Lung / pathology
  • Carcinoma, Non-Small-Cell Lung / radiotherapy
  • Clinical Trials as Topic
  • Combined Modality Therapy
  • Deoxycytidine / administration & dosage
  • Deoxycytidine / analogs & derivatives*
  • Docetaxel
  • Etoposide / administration & dosage
  • Female
  • Gemcitabine
  • Humans
  • Lung Neoplasms / drug therapy*
  • Lung Neoplasms / mortality
  • Lung Neoplasms / pathology
  • Lung Neoplasms / radiotherapy
  • Male
  • Microtubules / drug effects
  • Multicenter Studies as Topic
  • Neoadjuvant Therapy
  • Organoplatinum Compounds / administration & dosage
  • Paclitaxel / administration & dosage
  • Paclitaxel / analogs & derivatives*
  • Paclitaxel / therapeutic use*
  • Palliative Care
  • Podophyllotoxin / administration & dosage
  • Randomized Controlled Trials as Topic
  • Salvage Therapy
  • Survival Analysis
  • Taxoids*
  • Teniposide / administration & dosage
  • Treatment Outcome
  • Vinblastine / administration & dosage
  • Vinblastine / analogs & derivatives*
  • Vinorelbine

Substances

  • Angiogenesis Inhibitors
  • Antineoplastic Agents, Phytogenic
  • Organoplatinum Compounds
  • Taxoids
  • Deoxycytidine
  • Docetaxel
  • Vinblastine
  • Etoposide
  • Teniposide
  • Podophyllotoxin
  • Paclitaxel
  • Vinorelbine
  • Gemcitabine