Abstract
A general method for the deglycosidation of glycopeptide antibiotics has been developed. Treatment of vancomycin, ristocetin, and ramoplanin with anhydrous HF results in efficient cleavage of the sugars to provide the corresponding aglycons in high yield.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Anti-Bacterial Agents / chemistry*
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Chromatography, High Pressure Liquid
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Depsipeptides*
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Hydrofluoric Acid
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Indicators and Reagents
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Peptides, Cyclic / chemistry*
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Pyridines / chemistry
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Ristocetin / chemistry*
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Solvents
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Vancomycin / chemistry*
Substances
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Anti-Bacterial Agents
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Depsipeptides
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Indicators and Reagents
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Peptides, Cyclic
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Pyridines
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Solvents
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ramoplanin
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Ristocetin
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Vancomycin
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pyridine
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Hydrofluoric Acid