Abstract
We examined plasma chemokine concentrations and chemokine clearance rates in Duffy antigen knockout mice. The plasma concentrations of eotaxin and MCP-1 in Duffy antigen knockout mice were less than one-third of those in wild-type mice. When eotaxin or hMGSA was intravenously injected, the chemokine disappeared more rapidly from the plasma of Duffy antigen knockout mice than from the plasma of wild-type mice. The half-lives of hIP-10 and interferon-gamma, which do not have an affinity for the Duffy antigen, in plasma were indistinguishable between Duffy antigen knockout mice and wild-type mice. These results suggest that the Duffy antigen delays the disappearance of chemokines from the plasma, resulting in the maintenance of plasma chemokine concentrations.
MeSH terms
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Animals
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Antigens, Protozoan*
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Carrier Proteins / metabolism*
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Carrier Proteins / physiology*
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Chemokine CCL11
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Chemokine CXCL1
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Chemokine CXCL10
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Chemokines / blood*
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Chemokines / metabolism
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Chemokines / pharmacokinetics
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Chemokines, CC / blood
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Chemokines, CXC / metabolism
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Chemotactic Factors / pharmacokinetics
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Duffy Blood-Group System / genetics*
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Intercellular Signaling Peptides and Proteins / pharmacokinetics
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Interferon-gamma / pharmacokinetics
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Mice
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Mice, Knockout
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Protozoan Proteins / metabolism*
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Protozoan Proteins / physiology*
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Receptors, Cell Surface / metabolism*
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Receptors, Cell Surface / physiology*
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Time Factors
Substances
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Antigens, Protozoan
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Carrier Proteins
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Ccl11 protein, mouse
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Chemokine CCL11
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Chemokine CXCL1
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Chemokine CXCL10
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Chemokines
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Chemokines, CC
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Chemokines, CXC
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Chemotactic Factors
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Cxcl1 protein, mouse
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Duffy Blood-Group System
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Duffy antigen binding protein, Plasmodium
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Intercellular Signaling Peptides and Proteins
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Protozoan Proteins
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Receptors, Cell Surface
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Interferon-gamma