Abstract
Activation of a cytotoxic T cell requires specific binding of antigenic peptides to major histocompatibility complex (MHC) molecules. This paper reports a study of peptides binding to members of the HLA-A3 superfamily using a recently developed 2D-QSAR method, called the additive method. Four alleles with high phenotype frequency were included in the study: A*0301, A*1101, A*3101 and A*6801. The influence of each of the 20 amino acids at each position of the peptide on binding was studied. A refined A3 supertype motif was defined in the study.
MeSH terms
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Alleles
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Amino Acid Motifs
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Amino Acid Sequence
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Amino Acids / chemistry
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Amino Acids / genetics
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Amino Acids / metabolism
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Binding Sites
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HLA-A3 Antigen / chemistry*
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HLA-A3 Antigen / genetics
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HLA-A3 Antigen / immunology
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HLA-A3 Antigen / metabolism*
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Humans
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Models, Biological
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Molecular Sequence Data
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Oligopeptides / chemistry
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Oligopeptides / genetics
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Oligopeptides / metabolism
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Phenotype
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Protein Binding
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Quantitative Structure-Activity Relationship
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Recombinant Proteins / chemistry
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Recombinant Proteins / genetics
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Recombinant Proteins / metabolism
Substances
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Amino Acids
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HLA-A3 Antigen
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Oligopeptides
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Recombinant Proteins