Successful retransplantation using rapamycin in a patient with previous calcineurin inhibitor-induced posterior leukoencephalopathy syndrome

Clin Nephrol. 2003 Mar;59(3):225-8. doi: 10.5414/cnp59225.

Abstract

Posterior Leukoencephalopathy Syndrome (PLES) is a rare but serious neurological condition with many aetiologies. In the era of organ transplantation there have been sporadic reports of calcineurin-inhibitor associated PLES. We describe a case, with subsequent uneventful retransplantation using sirolimus.

Publication types

  • Case Reports

MeSH terms

  • Brain Diseases / chemically induced*
  • Brain Diseases / diagnosis
  • Calcineurin Inhibitors*
  • Cyclosporine / adverse effects
  • Graft Rejection / prevention & control
  • Humans
  • Immunosuppressive Agents / adverse effects
  • Immunosuppressive Agents / therapeutic use*
  • Kidney Transplantation*
  • Magnetic Resonance Imaging
  • Male
  • Reoperation
  • Sirolimus / therapeutic use*
  • Syndrome
  • Tacrolimus / adverse effects

Substances

  • Calcineurin Inhibitors
  • Immunosuppressive Agents
  • Cyclosporine
  • Sirolimus
  • Tacrolimus