Objective: To discuss the relationship between heterotopic neurons and intractable epilepsy.
Methods: Epileptogenic zones were precisely located with MRI, video-EEG monitoring, intracranial electrical recording and electrocorticography monitoring and then resected in seven patients. The removed tissue was processed for conventional pathological examination with immunohistochemical staining.
Results: Heterotopic neurons were found in the white matter of the specimens. All the seven cases experienced a favorable outcome, with six seizure free.
Conclusion: The heterotopic neurons scattered or clustered in the white matter contribute to the pathogenesis of intractable epilepsy.