Abstract
Currently available pneumococcal vaccines were examined for contamination by pneumococcal surface protein A (PspA) and pneumococcal surface adhesin A (PsaA). PspA could be detected in some (but not all) lots of 23-valent polysaccharide vaccine. Many lots of pneumococcal vaccines, including the heptavalent conjugate vaccine, were found to elicit small (but variable) antibody responses to PspA, PsaA, or both. The degree of contamination was highly variable, and this should be considered in pneumococcal vaccine evaluations or when capsular polysaccharide is used for pneumococcal antibody assays.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adhesins, Bacterial
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Adult
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Antibodies, Bacterial / analysis*
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Antigens, Bacterial / immunology
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Bacterial Proteins / analysis
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Bacterial Proteins / immunology*
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Carrier Proteins / immunology
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Drug Contamination*
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Humans
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Lipoproteins / immunology
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Membrane Transport Proteins*
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Pneumococcal Infections / blood
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Pneumococcal Infections / immunology*
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Pneumococcal Vaccines / immunology*
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Pneumococcal Vaccines / standards
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Streptococcus pneumoniae / immunology*
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Vaccination
Substances
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Adhesins, Bacterial
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Antibodies, Bacterial
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Antigens, Bacterial
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Bacterial Proteins
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Carrier Proteins
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Lipoproteins
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Membrane Transport Proteins
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Pneumococcal Vaccines
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PsaA protein, Streptococcus
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pneumococcal surface protein A