Abstract
The combined activity in vitro of amphotericin B/terbinafine and itraconazole/terbinafine was assessed against 17 clinical isolates of Zygomycota using a checkerboard technique. Itraconazole/terbinafine combination exhibited a potent synergistic effect against the most of strains. Amphotericin B/terbinafine combination showed an indifferent interaction for Rhizopus oryzae, and an additive effect for the other species.
Publication types
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Evaluation Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Amphotericin B / pharmacology*
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Antifungal Agents / pharmacology*
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Colony Count, Microbial
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Drug Interactions
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Female
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Fungi / drug effects*
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Fungi / isolation & purification
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Humans
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Itraconazole / pharmacology*
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Male
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Microbial Sensitivity Tests
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Mycoses / diagnosis
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Mycoses / drug therapy
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Naphthalenes / pharmacology*
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Sensitivity and Specificity
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Terbinafine
Substances
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Antifungal Agents
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Naphthalenes
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Itraconazole
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Amphotericin B
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Terbinafine