Abstract
Human CD46 is a cellular receptor for human herpesvirus 6 (HHV-6). Virus entry into host cells requires a glycoprotein H (gH)-glycoprotein L (gL) complex. We show that the CD46 ectodomain blocked HHV-6 infection and bound a complex of gH-gL and the 80-kDa U100 gene product, designated glycoprotein Q, indicating that the complex is a viral ligand for CD46.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antigens, CD / genetics
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Antigens, CD / metabolism*
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Baculoviridae / genetics
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Cell Fusion
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Cell Line
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Herpesvirus 6, Human / classification
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Herpesvirus 6, Human / genetics
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Herpesvirus 6, Human / pathogenicity*
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Humans
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Ligands
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Membrane Cofactor Protein
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Membrane Fusion
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Membrane Glycoproteins / genetics
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Membrane Glycoproteins / metabolism*
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Receptors, Virus / metabolism
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Recombinant Proteins / metabolism
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Viral Envelope Proteins / metabolism*
Substances
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Antigens, CD
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CD46 protein, human
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Ligands
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Membrane Cofactor Protein
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Membrane Glycoproteins
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Receptors, Virus
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Recombinant Proteins
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Viral Envelope Proteins
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glycoprotein H, herpesvirus 6