Abstract
In this preliminary report we present data showing that leukotrienes increase the baseline cell viability in human intestinal epithelial cells and that LTB4 partially reverses the morphological hallmarks of non-necrotic cell death induced by the COX-2 specific inhibitor NS-398. The proposed signaling mechanisms regulating these events are summarized in fig. 3. Please view the work on LT signal transduction in these cells by Thodeti et al. in this volume.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Line
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Cell Survival / drug effects
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Cell Survival / physiology*
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Cyclooxygenase Inhibitors / pharmacology
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Humans
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Intestinal Mucosa / cytology*
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Intestinal Mucosa / drug effects
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Intestinal Mucosa / physiology
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Leukotrienes / physiology*
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Nitrobenzenes / pharmacology
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Sulfonamides / pharmacology
Substances
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Cyclooxygenase Inhibitors
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Leukotrienes
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Nitrobenzenes
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Sulfonamides
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N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide