RNA-binding proteins that target the androgen receptor mRNA

Jackie A Wilce; Peter J Leedman; Matthew C J Wilce

doi:10.1080/15216540216033

RNA-binding proteins that target the androgen receptor mRNA

IUBMB Life. 2002 Dec;54(6):345-9. doi: 10.1080/15216540216033.

Authors

Jackie A Wilce¹, Peter J Leedman, Matthew C J Wilce

Affiliation

¹ Department of Biochemistry and Molecular Biology/Department of Chemistry, Western Australian Institute for Medical Research, University of Western Australia, Perth, Western Australia 6009, Australia. [email protected]

PMID: 12665245
DOI: 10.1080/15216540216033

Abstract

Recent efforts to elucidate mechanisms of posttranscriptional gene regulation have resulted in the description of both cis- and trans-acting factors which affect the stability and translational efficiency of specific mRNAs. Here we summarise some of the concepts in this field, with particular attention to recently discovered protein/RNA interactions involving the human androgen receptor mRNA. Such systems are of interest for their potential as targets for the modulation of protein production.

Publication types

Review

MeSH terms

Antigens, Surface*
Base Sequence
DNA-Binding Proteins
ELAV Proteins
ELAV-Like Protein 1
Gene Expression Regulation
Heterogeneous-Nuclear Ribonucleoproteins / chemistry
Humans
Models, Biological
Molecular Sequence Data
Nucleic Acid Conformation
Protein Binding
RNA / metabolism
RNA Processing, Post-Transcriptional
RNA, Messenger / metabolism*
RNA-Binding Proteins / chemistry
RNA-Binding Proteins / metabolism*
Receptors, Androgen / metabolism*

Substances

Antigens, Surface
DNA-Binding Proteins
ELAV Proteins
ELAV-Like Protein 1
ELAVL1 protein, human
Heterogeneous-Nuclear Ribonucleoproteins
PCBP1 protein, human
RNA, Messenger
RNA-Binding Proteins
Receptors, Androgen
RNA