[Preliminary investigation on the relation between clinical progress and anti-small monomolecular peptides antibody in individual infected with HIV]

Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2002 Sep;16(3):286-7.
[Article in Chinese]

Abstract

Objective: To study the quantity of anti-R7V in individuals infected with HIV and AIDS patients and its relation with the progression of disease.

Methods: ELISA and precipitation and other methods were used to investigate the quantity of anti-R7V in asymptomatic long-term survivors and AIDS patients.

Results: Positive rate and quantity of anti-R7V were higher in the HIV active ones and AIDS. It showed that the quantity and positive rate of anti-R7V were rather high in dissolving test.

Conclusions: It is strong suggestion for anti-R7V to obstruct the replication of virus by interfering the connection between HIV with CCR5 or CXCR4 and so it impossible HIV entering to CD4+ T cells.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acquired Immunodeficiency Syndrome / immunology*
  • Adolescent
  • Adult
  • Aged
  • Child
  • Female
  • Follow-Up Studies
  • HIV Antibodies / blood*
  • HIV Infections / immunology*
  • HIV Long-Term Survivors
  • HIV-1 / immunology*
  • Humans
  • Male
  • Middle Aged
  • Receptors, CCR5 / physiology
  • Receptors, CXCR4 / physiology

Substances

  • HIV Antibodies
  • Receptors, CCR5
  • Receptors, CXCR4