Expression of lysophosphatidic acid receptors and vascular endothelial growth factor mediating lysophosphatidic acid in the development of human ovarian cancer

Takuji Fujita; Shingo Miyamoto; Ichiro Onoyama; Kenzo Sonoda; Eisuke Mekada; Hitoo Nakano

doi:10.1016/s0304-3835(02)00713-9

Expression of lysophosphatidic acid receptors and vascular endothelial growth factor mediating lysophosphatidic acid in the development of human ovarian cancer

Cancer Lett. 2003 Mar 31;192(2):161-9. doi: 10.1016/s0304-3835(02)00713-9.

Authors

Takuji Fujita¹, Shingo Miyamoto, Ichiro Onoyama, Kenzo Sonoda, Eisuke Mekada, Hitoo Nakano

Affiliation

¹ Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan.

PMID: 12668280
DOI: 10.1016/s0304-3835(02)00713-9

Abstract

Lysophosphatidic acid (LPA) receptors including LPA(1), LPA(2), and LPA(3) mediate lysophosphatidic acid signals. We analyzed the expression of LPA receptors, vascular endothelial growth factor (VEGF), and interleukin-8 in 97 patients from normal ovary to ovarian cancer, using reverse transcription polymerase chain reaction. LPA(2), LPA(3), and VEGF expression ratios significantly increased in cancer, compared to those in non-cancerous state (P<0.05). A significant correlation in the expression ratios between LPA(2) or LPA(3) and VEGF was found (gamma=0.617, P<0.0001; gamma=0.431, P<0.001) in patients with cancer. These results suggested that LPA(2) and LPA(3) may be involved in VEGF expression mediated by LPA signals in human ovarian oncogenesis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Endothelial Growth Factors / genetics*
Female
Gene Expression Regulation, Neoplastic*
Humans
Intercellular Signaling Peptides and Proteins / genetics*
Interleukin-8 / genetics
Lymphokines / genetics*
Lysophospholipids / metabolism*
Neoplasm Staging
Ovarian Neoplasms / genetics*
Ovarian Neoplasms / pathology
RNA, Messenger / genetics
RNA, Messenger / metabolism
Receptors, Cell Surface / genetics*
Receptors, G-Protein-Coupled*
Receptors, Lysophosphatidic Acid
Reverse Transcriptase Polymerase Chain Reaction
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors

Substances

Endothelial Growth Factors
Intercellular Signaling Peptides and Proteins
Interleukin-8
Lymphokines
Lysophospholipids
RNA, Messenger
Receptors, Cell Surface
Receptors, G-Protein-Coupled
Receptors, Lysophosphatidic Acid
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors