Abstract
We report on 14 children (seven boys, seven girls) with chronic idiopathic thrombocytopenic purpura (ITP) refractory to multiple treatments, who were given a short-term therapy (range between 6 and 10 weeks) with high doses of cyclosporin A (CyA) (median, 10 mg/kg/d). Six patients experienced adverse events and one developed severe systemic mycosis during therapy. A complete response (CR) was observed in four patients and a partial response (PR) in three patients. Only the four CR patients, who were all girls, had a sustained response. These data suggest that CyA may be effective in some children with chronic symptomatic ITP.
Publication types
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Clinical Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Child
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Child, Preschool
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Chronic Disease
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Cyclosporine / administration & dosage*
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Cyclosporine / adverse effects
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Cyclosporine / therapeutic use
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Drug Administration Schedule
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Female
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Humans
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Immunosuppressive Agents / administration & dosage*
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Immunosuppressive Agents / adverse effects
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Immunosuppressive Agents / therapeutic use
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Male
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Mycoses / complications
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Platelet Count
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Purpura, Thrombotic Thrombocytopenic / blood
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Purpura, Thrombotic Thrombocytopenic / drug therapy*
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Purpura, Thrombotic Thrombocytopenic / microbiology
Substances
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Immunosuppressive Agents
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Cyclosporine