Cholinesterase inhibitory constituents from Onosma hispida

Chem Pharm Bull (Tokyo). 2003 Apr;51(4):412-4. doi: 10.1248/cpb.51.412.

Abstract

Hispidone, a new flavanone, has been isolated from Onosma hispida and assigned the structure (2S)-5,2'-dihydroxy-7,4',5'-trimethoxyflavanone (1) by spectroscopic methods. In addition, (2S)-5,2'-dihydroxy-7,5'-dimethoxyflavanone (2), benzoic acid (3), and 4-hydroxy benzoic acid (4) are also reported for the first time from this species.

MeSH terms

  • Animals
  • Boraginaceae*
  • Butyrylcholinesterase / metabolism
  • Cholinesterase Inhibitors / chemistry*
  • Cholinesterase Inhibitors / isolation & purification
  • Cholinesterase Inhibitors / pharmacology*
  • Horses
  • Plant Extracts / chemistry
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology
  • Plant Structures

Substances

  • Cholinesterase Inhibitors
  • Plant Extracts
  • Butyrylcholinesterase