Nasal-type NK/T cell lymphoma of the orbit with distant metastases

Hum Pathol. 2003 Mar;34(3):290-2. doi: 10.1053/hupa.2003.33.

Abstract

A case of a nasal-type NK/T cell lymphoma of the orbit with distant metastases is reported. The orbital lymphoma was angiodestructive with prominent necrosis and frequent apoptosis. Lymphoma cells were positive for CD56, cytotoxic molecules (granzyme B and TIA-1), and EBV. Despite local radiotherapy, the patient had a highly aggressive clinical course. A postmortem examination revealed distant metastases to the heart and lungs exhibiting angiocentric growth. TCR and Ig genes of a cardiac lesion were in germ line configuration. This case demonstrated that nasal-type NK/T cell lymphomas with a poor prognosis can occur in the orbit.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Aged, 80 and over
  • Apoptosis
  • Biopsy
  • CD56 Antigen / analysis
  • Fatal Outcome
  • Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
  • Gene Rearrangement, delta-Chain T-Cell Antigen Receptor
  • Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor
  • Heart Neoplasms / genetics
  • Heart Neoplasms / pathology
  • Herpesvirus 4, Human / genetics
  • Herpesvirus 4, Human / isolation & purification
  • Humans
  • Immunophenotyping
  • Killer Cells, Natural*
  • Lung Neoplasms / pathology
  • Lymphoma, T-Cell / diagnosis*
  • Lymphoma, T-Cell / pathology
  • Lymphoma, T-Cell / virology
  • Magnetic Resonance Imaging
  • Male
  • Necrosis
  • Orbit / pathology
  • Orbital Neoplasms / diagnosis*
  • Orbital Neoplasms / pathology
  • Orbital Neoplasms / virology
  • RNA, Viral / analysis

Substances

  • CD56 Antigen
  • RNA, Viral