Abstract
Both fertilization promoting peptide and adenosine stimulate capacitation but inhibit spontaneous acrosome loss by modulation of the adenylyl cyclase (AC)/cAMP signal transduction pathway. This is a review aimed at analyzing the function of fertilization promoting peptide during this process. The possible molecular basis is also discussed.
Publication types
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English Abstract
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Acrosome / drug effects
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Adenylyl Cyclases / metabolism
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Animals
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Cyclic AMP / metabolism
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Humans
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Male
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Pyrrolidonecarboxylic Acid / analogs & derivatives
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Signal Transduction / drug effects
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Spermatozoa / drug effects*
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Spermatozoa / physiology
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Thyrotropin-Releasing Hormone / analogs & derivatives*
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Thyrotropin-Releasing Hormone / pharmacology*
Substances
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Thyrotropin-Releasing Hormone
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pyroglutamyl-glutamyl-proline amide
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Cyclic AMP
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Adenylyl Cyclases
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Pyrrolidonecarboxylic Acid