Abstract
Different members of the Notch family have been described to play a critical role in T cell lineage commitment and T cell development and functions. Nevertheless, whether they act as redundant molecules, by affecting the same molecular mechanisms, or play distinct roles in T cell differentiation and/or functions is not clear. Altered Notch3 signaling impairs the developmentally regulated interplay between pre-TCR and NF-kappaB signaling and allows the disruption of early thymocyte differentiation and the development of T cell leukemia, thus identifying the crucial role of Notch3 receptor in the coordination of T cell differentiation and growth control.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cell Lineage
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Mice
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Models, Biological
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NF-kappa B / metabolism
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Proto-Oncogene Proteins / agonists
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Proto-Oncogene Proteins / physiology*
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Receptor, Notch3
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Receptor, Notch4
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Receptors, Antigen, T-Cell / antagonists & inhibitors
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Receptors, Antigen, T-Cell / immunology
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Receptors, Cell Surface*
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Receptors, Notch
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Signal Transduction
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T-Lymphocytes / immunology*
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Thymus Gland / growth & development
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Thymus Gland / immunology*
Substances
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NF-kappa B
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NOTCH3 protein, human
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Notch3 protein, mouse
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Proto-Oncogene Proteins
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Receptor, Notch3
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Receptor, Notch4
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Receptors, Antigen, T-Cell
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Receptors, Cell Surface
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Receptors, Notch
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Notch4 protein, mouse