All roads lead to ATF4

Dev Cell. 2003 Apr;4(4):442-4. doi: 10.1016/s1534-5807(03)00100-x.

Abstract

Multiple intracellular stress pathways converge on a single event--phosphorylation of the translation initiation factor eIF2alpha and subsequent translational activation of the transcription factor ATF4. Exploring the consequences of this event has highlighted the ways in which stress is sensed and responded to via many distinct pathways.

Publication types

  • Review

MeSH terms

  • Activating Transcription Factor 4
  • Animals
  • Antioxidants / metabolism
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism
  • Endoplasmic Reticulum / metabolism
  • Eukaryotic Cells / metabolism*
  • Humans
  • Proteins / genetics
  • Proteins / metabolism*
  • Signal Transduction / genetics*
  • Stress, Physiological / genetics
  • Stress, Physiological / metabolism*
  • Transcription Factors / genetics*
  • Transcription Factors / metabolism
  • eIF-2 Kinase / genetics
  • eIF-2 Kinase / metabolism

Substances

  • ATF4 protein, human
  • Antioxidants
  • DNA-Binding Proteins
  • Proteins
  • Transcription Factors
  • Activating Transcription Factor 4
  • PERK kinase
  • eIF-2 Kinase