SETting the stage. Eed-Enx1 leaves an epigenetic signature on the inactive X chromosome

Dev Cell. 2003 Apr;4(4):445-7. doi: 10.1016/s1534-5807(03)00097-2.

Abstract

Despite evidence implicating the Polycomb group protein, Eed (embryonic ectoderm development protein) in imprinted X inactivation, a similar role in random X inactivation in the embryo has remained an open question. Brockdorff and colleagues now report that Eed, along with its binding partner Enx1, transiently associates with the inactive X chromosome (Xi) and likely contributes to the epigenetic signature and long-term stability of the Xi heterochromatin.

Publication types

  • Review
  • Comment

MeSH terms

  • Animals
  • Dosage Compensation, Genetic*
  • Eukaryotic Cells / metabolism*
  • Gene Expression Regulation / genetics
  • Histone Methyltransferases
  • Histone-Lysine N-Methyltransferase*
  • Humans
  • Methyltransferases / genetics
  • Methyltransferases / metabolism
  • Polycomb Repressive Complex 2
  • Polycomb-Group Proteins
  • Protein Methyltransferases
  • RNA, Long Noncoding
  • RNA, Untranslated / genetics
  • Repressor Proteins / genetics*
  • Totipotent Stem Cells / metabolism*
  • X Chromosome / genetics*

Substances

  • EED protein, human
  • Polycomb-Group Proteins
  • RNA, Long Noncoding
  • RNA, Untranslated
  • Repressor Proteins
  • XIST non-coding RNA
  • Histone Methyltransferases
  • Methyltransferases
  • Protein Methyltransferases
  • Histone-Lysine N-Methyltransferase
  • Polycomb Repressive Complex 2