Abstract
Allergic reactions to concentrates containing factor IX (FIX) are serious complications in the treatment of haemophilia B patients with inhibitor. We have established a therapeutic protocol for such cases using an initial skin test followed by step-wise infusions of FIX concentrates under hydrocortisone cover. We have successfully treated three patients whose treatment with FIX had been suspended.
MeSH terms
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Anaphylaxis / chemically induced*
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Anti-Inflammatory Agents / therapeutic use
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Child
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Clinical Protocols
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Drug Administration Schedule
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Drug Eruptions / etiology
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Factor IX / adverse effects*
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Factor IX / antagonists & inhibitors
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Factor IX / therapeutic use
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Hemophilia B / drug therapy*
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Humans
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Hydrocortisone / therapeutic use
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Skin Tests
Substances
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Anti-Inflammatory Agents
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Factor IX
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Hydrocortisone