Abstract
Computer-based molecular design has been used to produce a series of new macrocyclic systems targeted against the bacterial cell wall biosynthetic enzyme MurD. Following their preparation, which involved a novel metathesis-based cyclisation as the key step, these systems were found to show good inhibition when assayed against the MurD enzyme.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Binding Sites
-
Cell Wall / chemistry
-
Cell Wall / metabolism
-
Computer-Aided Design
-
Drug Design
-
Enzyme Inhibitors / chemical synthesis*
-
Enzyme Inhibitors / chemistry
-
Escherichia coli / chemistry*
-
Heterocyclic Compounds / chemical synthesis*
-
Heterocyclic Compounds / chemistry
-
Models, Molecular
-
Peptide Synthases / antagonists & inhibitors*
-
Peptide Synthases / chemistry
-
Stereoisomerism
-
Structure-Activity Relationship
Substances
-
Enzyme Inhibitors
-
Heterocyclic Compounds
-
Peptide Synthases
-
UDP-N-acetylmuramoylalanine-D-glutamate ligase