Abstract
V gamma 9V delta 2 T lymphocytes strongly respond to phosphoantigens from Plasmodium parasites. Thus, we analyzed the changes in V gamma 9V delta 2 T-cell function and repertoire during the paroxysm phase of nonendemic malaria infection. During malaria paroxysm, V gamma 9V delta 2 T cells were early activated but rapidly became anergic and finally loose J gamma 1.2 V gamma 9 complementarity-determining region 3 transcripts.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Complementarity Determining Regions / genetics*
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Female
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HLA-DR Antigens / analysis
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Humans
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Immune Tolerance*
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Malaria, Falciparum / immunology*
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Male
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Middle Aged
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Receptors, Antigen, T-Cell, gamma-delta / genetics
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Receptors, Antigen, T-Cell, gamma-delta / physiology*
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T-Lymphocyte Subsets / immunology*
Substances
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Complementarity Determining Regions
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HLA-DR Antigens
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Receptors, Antigen, T-Cell, gamma-delta