Dopamine D2 receptor gene Ser311Cys variant and schizophrenia: association study and meta-analysis

Am J Med Genet B Neuropsychiatr Genet. 2003 May 15;119B(1):28-34. doi: 10.1002/ajmg.b.20004.

Abstract

An association has been reported between a dopamine D(2) receptor gene (DRD2) Ser311Cys variant and schizophrenia. In a replication attempt, Swedish patients with schizophrenia (n = 173) and control subjects (n = 236) were assessed for the DRD2 Ser311Cys variant. Schizophrenic patients displayed higher Cys311 allele frequencies than control subjects (4.0 vs. 0.8%, chi(2) = 9.49, df = 1, P = 0.002; odds ratio (OR) 4.93, 95% confidence interval (95% CI) 1.61-15.12). The association was detected only in men. The results were supported by a meta-analysis of all published case-control studies comprising a total of 9,152 subjects (chi(2) = 11.37, df = 1, P < 0.001; OR 1.43, 95% CI 1.16-1.78). The present results support the involvement of the DRD2 gene in the pathogenesis of schizophrenia.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Amino Acid Substitution
  • Case-Control Studies
  • Female
  • Gene Frequency
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Genetic*
  • Receptors, Dopamine D2 / genetics*
  • Schizophrenia / etiology
  • Schizophrenia / genetics*
  • Sex Factors
  • Sweden

Substances

  • Receptors, Dopamine D2