Abstract
Assay-guided fractionation of the ethanol extract of Nymphaea odorata resulted in the identification of two lignans, one new (1) and one known (2), together with six known flavonol glycosides (3-8). The structures of 1-8 were established by spectroscopic analysis as nymphaeoside A (1), icariside E(4) (2), kaempferol 3-O-alpha-l-rhamnopyranoside (afzelin, 3), quercetin 3-O-alpha-l-rhamnopyranoside (4), myricetin 3-O-alpha-l-rhamnopyranoside (myricitrin, 5), quercetin 3-O-(6' '-O-acetyl)-beta-d-galactopyranoside (6), myricetin 3-O-beta-d-galactopyranoside (7), and myricetin 3-O-(6' '-O-acetyl)-beta-d-galactopyranoside (8). Compounds 3, 4, and 7 showed marginal inhibitory effect against fatty acid synthase with IC(50) values of 45, 50, and 25 microg/mL, respectively.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification*
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Enzyme Inhibitors / pharmacology
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Fatty Acid Synthases / antagonists & inhibitors*
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Flavonoids / chemistry
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Flavonoids / isolation & purification*
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Flavonoids / pharmacology
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Florida
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Glycosides / chemistry
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Glycosides / isolation & purification*
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Glycosides / pharmacology
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Hydrolysis
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Inhibitory Concentration 50
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Lignans / chemistry
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Lignans / isolation & purification*
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Lignans / pharmacology
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Nymphaea / chemistry*
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Phenols / chemistry
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Phenols / isolation & purification*
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Phenols / pharmacology
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Plant Leaves / chemistry
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Plants, Medicinal / chemistry*
Substances
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Enzyme Inhibitors
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Flavonoids
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Glycosides
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Lignans
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Phenols
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nymphaeoside A
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Fatty Acid Synthases