Abstract
Five new dihydro-beta-agarofuran sesquiterpenes (1-5) were isolated from the leaves of Maytenus chiapensis. The structures of 1-5 were determined by means of 1D and 2D NMR techniques. A semiselective HMBC technique was applied in order to obtain complete (13)C NMR assignments. Absolute configurations were determined by CD studies and chemical correlations and on biogenetic grounds. Compound 4 showed weak activity against a multidrug-resistant Leishmania tropica line.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Carbon Isotopes
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Cell Line / drug effects
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Circular Dichroism
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Drug Resistance, Multiple
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El Salvador
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Leishmania tropica / drug effects*
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Maytenus / chemistry*
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plant Leaves / chemistry
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Plants, Medicinal / chemistry*
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes / pharmacology
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Stereoisomerism
Substances
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Carbon Isotopes
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Sesquiterpenes