Synthesis and antifungal activity of (+/-)-1-(5-aryl-3-pyridin-2-yl-4,5-dihydro-pyrazol-1-yl)-2-imidazol-1-yl-ethanone derivatives

Maria Grazia Mamolo; Daniele Zampieri; Valeria Falagiani; Luciano Vio; Elena Banfi

doi:10.1016/S0014-827X(02)00006-X

Synthesis and antifungal activity of (+/-)-1-(5-aryl-3-pyridin-2-yl-4,5-dihydro-pyrazol-1-yl)-2-imidazol-1-yl-ethanone derivatives

Farmaco. 2003 Apr;58(4):315-22. doi: 10.1016/S0014-827X(02)00006-X.

Authors

Maria Grazia Mamolo¹, Daniele Zampieri, Valeria Falagiani, Luciano Vio, Elena Banfi

Affiliation

¹ Dipartimento di Scienze Farmaceutiche, Università di Trieste, Piazzale Europa 1, I-34127, Trieste, Italy. [email protected]

PMID: 12727541
DOI: 10.1016/S0014-827X(02)00006-X

Abstract

(+/-)-1-(5-Aryl-3-pyridin-2-yl-4,5-dihydro-pyrazol-1-yl)-2-imidazol-1-yl-ethanone derivatives were synthesized and tested for their in vitro antifungal activity. The compounds showed a moderate activity against strains of Candida parapsilosis, Candida pseudotropicalis and Candida glabrata.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antifungal Agents / chemical synthesis
Antifungal Agents / pharmacology*
Candida / drug effects
Drug Design
Imidazoles / chemical synthesis
Imidazoles / pharmacology*
Microbial Sensitivity Tests
Pyrazoles / chemical synthesis
Pyrazoles / pharmacology*
Pyridines / chemical synthesis
Pyridines / pharmacology*

Substances

Antifungal Agents
Imidazoles
Pyrazoles
Pyridines