Abstract
[11C]Edrophonium and its analogues have been synthesized for evaluation as new potential positron emission tomography (PET) imaging agents for heart acetylcholinesterase. The tracers were prepared by N-[11C]methylation of precursors using [11C]methyl triflate and isolated by solid-phase extraction (SPE) purification procedure in 50-65% radiochemical yields.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Carbon Radioisotopes*
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Cholinesterase Inhibitors / chemical synthesis
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Edrophonium / analogs & derivatives*
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Edrophonium / chemical synthesis
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Equipment Design
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Heart / diagnostic imaging
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Humans
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Radiopharmaceuticals / chemical synthesis*
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Tomography, Emission-Computed / methods*
Substances
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Carbon Radioisotopes
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Cholinesterase Inhibitors
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Radiopharmaceuticals
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Edrophonium