Abstract
In an effort to identify orally bioavailable factor Xa inhibitors, two isoxazolines libraries were prepared to scan for novel P1 ligands. From this work, 4-chloro-3-aniline was identified as a novel and potent benzamidine mimic.
MeSH terms
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Animals
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Benzamidines / chemistry
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Combinatorial Chemistry Techniques*
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Enzyme Inhibitors / chemical synthesis
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Factor Xa Inhibitors*
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Humans
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Isoxazoles / chemical synthesis*
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Isoxazoles / pharmacology
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Molecular Mimicry
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Structure-Activity Relationship
Substances
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Benzamidines
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Enzyme Inhibitors
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Factor Xa Inhibitors
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Isoxazoles
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benzamidine