[Expression of co-receptor on different T lymphocytes subpopulations after effective HAART]

Zhejiang Da Xue Xue Bao Yi Xue Ban. 2003 Apr;32(2):97-100. doi: 10.3785/j.issn.1008-9292.2003.02.004.
[Article in Chinese]

Abstract

Objective: To measure CCR5 and CXCR4 chemokine receptor expression on CD4 and CD8 T cells in HIV-1 infection and to relate levels to the distribution of CD45RO memory and CD45RA-naive subsets after effective HAART.

Methods: Four-color cytofluorometry with appropriate conjugated monoclonal antibodies (mAbs) was performed to define CD45RA and CD45RO subsets of CD4 and CD8 T cells and measure the expression of CCR5, CXCR4 in blood from 43 received HAART patients and 5 non-treated HIV and 13 healthy controls.

Results: The levels of CCR5 and CXCR4 on CD4 and CD8 T cells and their CD45RO/CD45RA subsets in HIV-1-infected patients had not any statistical significance than that on control subjects and effective HAART could adjust the expression on T cells.

Conclusion: CXCR4/CCR5 plays an important role in the progress of HIV-1 infection. The most favorable condition for treatment should be initiated before stage B.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acquired Immunodeficiency Syndrome / drug therapy*
  • Acquired Immunodeficiency Syndrome / immunology
  • Antiretroviral Therapy, Highly Active*
  • CD4-Positive T-Lymphocytes / chemistry*
  • CD8-Positive T-Lymphocytes / chemistry*
  • HIV-1*
  • Humans
  • Receptors, CCR5 / blood
  • Receptors, CCR5 / drug effects*
  • Receptors, CXCR4 / blood
  • Receptors, CXCR4 / drug effects*

Substances

  • Receptors, CCR5
  • Receptors, CXCR4