Abstract
Preprodynorphin mRNA was measured in the nucleus accumbens (NAc) and caudate putamen (CPu) after 3-day 'binge' pattern cocaine administration in C57BL/6J and 129/J mice, strains which differ in behavior and in dopamine increases in the CPu after 'binge' cocaine. In the CPu, there was increased preprodynorphin mRNA in C57BL/6J (P<0.05), but not in 129/J mice, with no differences in the NAc. Thus, 129/J mice are hyporesponsive to the preprodynorphin activating effects of acute 'binge' cocaine in the CPu.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Behavior, Animal / drug effects
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Caudate Nucleus / drug effects
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Caudate Nucleus / metabolism*
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Cocaine / administration & dosage
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Cocaine / pharmacology
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Cocaine-Related Disorders / metabolism*
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Dose-Response Relationship, Drug
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Dynorphins / biosynthesis*
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Mice
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Mice, Inbred C57BL
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Mice, Inbred Strains
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Protein Precursors / biosynthesis
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Putamen / drug effects
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Putamen / metabolism*
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RNA, Messenger / biosynthesis*
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Species Specificity
Substances
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Protein Precursors
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RNA, Messenger
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pre-prodynorphin
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Dynorphins
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Cocaine