Background: Topical nitrogen mustard solution has been used as an effective alternative to corticosteroids for the treatment of cutaneous eruptions of Langerhans' cell histiocytosis (LCH). When used as an ointment under occlusion, nitrogen mustard may still be effective and possess less risk of unwanted side effects.
Methods: A patient with scalp LCH was treated topically with nitrogen mustard ointment 0.01% under occlusion.
Results: The lesions cleared in 3 weeks without irritation.
Conclusion: Topical nitrogen mustard ointment 0.01% under occlusion is a well-tolerated, non-irritating treatment for scalp LCH.