Abstract
Using an HBV-producing cell line and inhibition of the expression of the HBsAg and HBeAg as antiviral indicators, a study was conducted on 25 compounds isolated from four Phyllanthus (Euphorbiaceae) plants, including P. amarus Schum. & Thonn., P. multi florus Willd., P. tenellus Roxb. and P. virgatus Forst. f. It was found that niranthin (1), nirtetralin (3), hinokinin (5) and geraniin (13) at the non-cytotoxic concentration of 50 micro m, suppressed effectively both HBsAg and HBeAg expression, with the highest inhibition at 74.3%, 45.3%; 69.6%, 33.9%; 68.1%, 52.3%; 32.1%, 46.6%, respectively. Of these, niranthin (1) showed the best anti-HBsAg activity, while the most potent anti-HBeAg activity was observed with hinokinin (5).
Copyright 2003 John Wiley & Sons, Ltd.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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4-Butyrolactone / analogs & derivatives
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4-Butyrolactone / isolation & purification
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4-Butyrolactone / pharmacology*
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Anisoles / isolation & purification
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Anisoles / pharmacology*
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Benzodioxoles
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Culture Techniques
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Dioxoles / isolation & purification
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Dioxoles / pharmacology*
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Enzyme-Linked Immunosorbent Assay
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Glucosides / isolation & purification
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Glucosides / pharmacology
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Hepatitis B Surface Antigens / biosynthesis
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Hepatitis B Surface Antigens / drug effects
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Hepatitis B e Antigens / biosynthesis
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Hepatitis B e Antigens / drug effects
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Hepatitis B virus / drug effects*
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Hepatitis B virus / growth & development
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Hepatitis B virus / metabolism
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Humans
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Hydrolyzable Tannins*
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Lignans*
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Molecular Structure
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Phyllanthus*
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Phytotherapy
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Plant Extracts / chemistry
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Plant Extracts / pharmacology*
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Tannins / isolation & purification
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Tannins / pharmacology
Substances
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Anisoles
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Benzodioxoles
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Dioxoles
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Glucosides
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Hepatitis B Surface Antigens
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Hepatitis B e Antigens
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Hydrolyzable Tannins
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Lignans
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Plant Extracts
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Tannins
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hinokinin
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niranthin
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nirtetralin
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Geraniin
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4-Butyrolactone