Abstract
The resistance patterns and macrolide resistance mechanisms of 910 Finnish invasive pneumococci isolated during 1999 and 2000 were studied. Macrolide resistance was detected in 6.9% of isolates. Penicillin resistance was detected in 1.5% of isolates, and penicillin intermediate resistance was detected in 4.0% of isolates. Active macrolide efflux, mediated by the mef(A) gene, was the most common macrolide resistance mechanism. Four macrolide-resistant isolates had mutations in rRNA or ribosomal protein L22.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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DNA, Bacterial / chemistry
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DNA, Bacterial / genetics
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Drug Resistance, Bacterial
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Drug Resistance, Multiple
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Finland
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Humans
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Macrolides
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Microbial Sensitivity Tests
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Pneumococcal Infections / microbiology
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Polymerase Chain Reaction
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Streptococcus pneumoniae / drug effects*
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Streptococcus pneumoniae / genetics
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Streptococcus pneumoniae / growth & development
Substances
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Anti-Bacterial Agents
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DNA, Bacterial
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Macrolides