Abstract
Staphylococcus aureus is a prevalent cause of bacterial infections associated with indwelling medical devices. RNA III inhibiting peptide (RIP) is known to inhibit S. aureus pathogenesis by disrupting quorum-sensing mechanisms. RIP was tested in the present study for its ability to inhibit S. aureus biofilm formation in a rat Dacron graft model. The activity of RIP was synergistic with those of antibiotics for the complete prevention of drug-resistant S. aureus infections.
MeSH terms
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Animals
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Anti-Bacterial Agents / pharmacology
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Antibiotic Prophylaxis
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Biofilms / drug effects
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Biofilms / growth & development*
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Cell Communication / drug effects
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Colony Count, Microbial
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Drug Synergism
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Male
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Microbial Sensitivity Tests
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Oligopeptides / pharmacology*
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Polyethylene Terephthalates
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Prostheses and Implants / microbiology*
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Rats
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Rats, Wistar
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Staphylococcal Infections / drug therapy*
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Staphylococcus aureus / drug effects*
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Staphylococcus aureus / growth & development*
Substances
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Anti-Bacterial Agents
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Oligopeptides
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Polyethylene Terephthalates
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RNAIII inhibiting peptide