Abstract
Blood and pleural exudate samples were obtained from 16 patients receiving intermittent or continuous infusions of vancomycin after lung surgery. The areas under the concentration-time curves for blood and pleural exudates were identical for both administration schedules, while continuous infusion allowed the concentrations in pleural exudates to be more sustained (mean concentration, 12 mg/liter).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / blood
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Anti-Bacterial Agents / pharmacokinetics*
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Area Under Curve
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Bronchial Neoplasms / drug therapy
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Bronchial Neoplasms / metabolism
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Drug Administration Schedule
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Exudates and Transudates / metabolism
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Female
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Humans
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Infusions, Intravenous
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Male
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Middle Aged
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Pleural Effusion, Malignant / metabolism*
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Vancomycin / administration & dosage
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Vancomycin / blood
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Vancomycin / pharmacokinetics*
Substances
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Anti-Bacterial Agents
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Vancomycin