Two new xanthone derivatives from the algicolous marine fungus Wardomyces anomalus

J Nat Prod. 2003 May;66(5):706-8. doi: 10.1021/np020518b.

Abstract

A marine fungal isolate, identified as Wardomyces anomalus, was cultivated and found to produce two new xanthone derivatives, 2,3,6,8-tetrahydroxy-1-methylxanthone (1) and 2,3,4,6,8-pentahydroxy-1-methylxanthone (2), in addition to the known xanthone derivative 3,6,8-trihydroxy-1-methylxanthone (3) and the known fungal metabolite 5-(hydroxymethyl)-2-furanocarboxylic acid (4). The structures of all compounds were determined on the basis of extensive spectroscopic measurements (1D and 2D NMR, MS, UV, and IR). Compounds 1 and 4 showed significant antioxidant activities. The total extract and 1, 3, and 4 were shown to be inhibitors of p56(lck)tyrosine kinase.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antioxidants / chemistry
  • Antioxidants / isolation & purification*
  • Antioxidants / pharmacology
  • Fungi / chemistry*
  • Fungi / classification
  • HIV Reverse Transcriptase / drug effects*
  • Lymphocyte Specific Protein Tyrosine Kinase p56(lck) / drug effects*
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Xanthenes / chemistry
  • Xanthenes / isolation & purification*
  • Xanthenes / pharmacology
  • Xanthones*

Substances

  • 2,3,4,6,8-pentahydroxy-1-methylxanthone
  • 2,3,6,8-tetrahydroxy-1-methylxanthone
  • Antioxidants
  • Xanthenes
  • Xanthones
  • xanthone
  • Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
  • HIV Reverse Transcriptase