Abstract
Dorsoventral patterning of the telencephalon is established early in forebrain development and underlies many of the regional subdivisions that are critical to the later organization of neural circuits in the cerebral cortex and basal ganglia. Sonic hedgehog (Shh) is involved in the generation of the ventral-most telencephalic cells, but the identity of the extrinsic signal(s) that induce dorsal character in telencephalic cells is not known. Here we show in chick embryos that sequential Wnt and fibroblast growth factor (FGF) signaling specifies cells of dorsal telencephalic character.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aging / genetics
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Aging / metabolism
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Animals
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Basic Helix-Loop-Helix Transcription Factors
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Bone Morphogenetic Proteins / physiology
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Cell Differentiation
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Chick Embryo
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Ectoderm / cytology
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Ectoderm / physiology
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Embryonic Induction / physiology*
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Epithelium
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Eye Proteins
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Fibroblast Growth Factors / classification
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Fibroblast Growth Factors / genetics
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Fibroblast Growth Factors / physiology*
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Frizzled Receptors
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Gene Expression Regulation, Developmental*
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Homeodomain Proteins / genetics
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Homeodomain Proteins / metabolism
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Immunohistochemistry
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In Situ Hybridization / methods
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Mice
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Nerve Tissue Proteins / genetics
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Nerve Tissue Proteins / metabolism
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Organ Culture Techniques
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PAX6 Transcription Factor
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Paired Box Transcription Factors
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Proteins / physiology
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Proto-Oncogene Proteins / genetics
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Proto-Oncogene Proteins / physiology*
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Pyrroles / pharmacology
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Receptors, Fibroblast Growth Factor / physiology
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Repressor Proteins
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Signal Transduction / genetics
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Signal Transduction / physiology*
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Stem Cells / metabolism
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Telencephalon / cytology
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Telencephalon / embryology
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Telencephalon / metabolism
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Telencephalon / physiology*
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Transcription Factors
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Wnt Proteins
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Zebrafish Proteins*
Substances
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Basic Helix-Loop-Helix Transcription Factors
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Bone Morphogenetic Proteins
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Eye Proteins
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Frizzled Receptors
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Homeodomain Proteins
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Mrg1 protein, mouse
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Nerve Tissue Proteins
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Neurog2 protein, mouse
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PAX6 Transcription Factor
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Paired Box Transcription Factors
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Pax6 protein, mouse
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Proteins
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Proto-Oncogene Proteins
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Pyrroles
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Receptors, Fibroblast Growth Factor
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Repressor Proteins
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SU 5402
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Transcription Factors
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Wnt Proteins
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Zebrafish Proteins
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empty spiracles homeobox proteins
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meis2b protein, zebrafish
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Fibroblast Growth Factors