Possible increased risk for Alzheimer's disease associated with neprilysin gene

J Neural Transm (Vienna). 2003 Jun;110(6):651-7. doi: 10.1007/s00702-002-0807-3.

Abstract

Neprilysin has recently been reported to be the major physiological Abeta-degradating enzyme. In this study we describe a new biallelic polymorphism in the 3'UTR of the neprilysin gene in a representative population sample. The (*)159C/C genotype was found to be associated with an increased risk for Alzheimer's disease in an age-dependent manner. Adjusting for sex and APOE status, an odds ratio of 2.74 (p < 0.05) was observed among patients under 75 years old.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3' Untranslated Regions / genetics
  • Age Factors
  • Aged
  • Alleles
  • Alzheimer Disease / enzymology
  • Alzheimer Disease / genetics*
  • Alzheimer Disease / physiopathology
  • Amyloid beta-Peptides / metabolism*
  • Brain / enzymology*
  • Brain / physiopathology
  • Case-Control Studies
  • Female
  • Genetic Predisposition to Disease / genetics*
  • Genetic Testing
  • Genotype
  • Humans
  • Male
  • Neprilysin / genetics*
  • Neprilysin / metabolism
  • Polymorphism, Genetic / genetics

Substances

  • 3' Untranslated Regions
  • Amyloid beta-Peptides
  • Neprilysin