Abstract
Reported are three children with MS who responded dramatically to interferon-beta (IFNbeta) therapy. While on immunomodulatory therapy, they developed chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) that responded to IV immunoglobulin (IVIG) administration. These cases emphasize two interesting observations: 1) IFNbeta treatment did not prevent development of CIDP; 2) CIDP in the context of MS responded to IVIG, even though IVIG had no therapeutic effect on the central demyelinating disease.
Publication types
-
Case Reports
-
Comparative Study
MeSH terms
-
Autoimmune Diseases of the Nervous System / therapy
-
Child
-
Child, Preschool
-
Female
-
Humans
-
Immunoglobulins, Intravenous / therapeutic use*
-
Interferon beta-1a
-
Interferon-beta / adverse effects
-
Interferon-beta / therapeutic use*
-
Male
-
Multiple Sclerosis / complications
-
Multiple Sclerosis / therapy*
-
Organ Specificity
-
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / complications
-
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / therapy*
-
Treatment Outcome
Substances
-
Immunoglobulins, Intravenous
-
Interferon-beta
-
Interferon beta-1a