Are diet-prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men

D Gunnell; S E Oliver; T J Peters; J L Donovan; R Persad; M Maynard; D Gillatt; A Pearce; F C Hamdy; D E Neal; J M P Holly

doi:10.1038/sj.bjc.6600946

Are diet-prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men

Br J Cancer. 2003 Jun 2;88(11):1682-6. doi: 10.1038/sj.bjc.6600946.

Authors

D Gunnell¹, S E Oliver, T J Peters, J L Donovan, R Persad, M Maynard, D Gillatt, A Pearce, F C Hamdy, D E Neal, J M P Holly

Affiliation

¹ Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, UK. [email protected]

Abstract

We examined the association of diet with insulin-like growth factors (IGF) in 344 disease-free men. Raised levels of IGF-I and/or its molar ratio with IGFBP-3 were associated with higher intakes of milk, dairy products, calcium, carbohydrate and polyunsaturated fat; lower levels with high vegetable consumption, particularly tomatoes. These patterns support the possibility that IGFs may mediate some diet-cancer associations.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Case-Control Studies
Cross-Sectional Studies
Diet*
Feeding Behavior
Humans
Insulin-Like Growth Factor Binding Protein 3 / blood*
Insulin-Like Growth Factor I / metabolism*
Male
Middle Aged
Prostatic Neoplasms / blood
Prostatic Neoplasms / epidemiology*
Risk Factors

Substances

Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor I