Abstract
The search for cell-surface markers that can distinguish T helper 1 (T(H)1) cells from T(H)2 cells has led to the identification of a new gene family, encoding the T-cell immunoglobulin mucin (TIM) proteins, some of which are differentially expressed by T(H)1 and T(H)2 cells. The role of the TIM-family proteins in immune regulation is just beginning to emerge. Here, we describe the various TIM-family members in mice and humans, and discuss the genetic and functional evidence for their role in regulating autoimmune and allergic diseases.
MeSH terms
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Animals
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Asthma / genetics
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Asthma / immunology
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Autoimmune Diseases / genetics
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Autoimmune Diseases / immunology
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Genetic Linkage
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Hepatitis A Virus Cellular Receptor 1
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Hepatitis A Virus Cellular Receptor 2
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Humans
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Interleukin-4 / biosynthesis
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Macrophage Activation
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Membrane Proteins / genetics*
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Membrane Proteins / immunology
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Mice
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Polymorphism, Genetic
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Receptors, Virus
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Th1 Cells / immunology*
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Th2 Cells / immunology*
Substances
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HAVCR2 protein, human
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Havcr1 protein, mouse
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Hepatitis A Virus Cellular Receptor 1
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Hepatitis A Virus Cellular Receptor 2
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Membrane Proteins
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Receptors, Virus
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Timd2 protein, mouse
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Interleukin-4