Abstract
We previously reported that stable transfection of protein kinase C alpha (PKCalpha) into T47D human breast cancer cells results in tamoxifen (TAM)-resistant tumour growth. Relevance of PKCalpha expression in clinical specimens was determined by comparing PKCalpha expression in tumours from patients exhibiting disease recurrence with patients remaining disease-free following TAM treatment. Our results suggest that PKCalpha expression may predict TAM treatment failure.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Antineoplastic Agents, Hormonal / therapeutic use
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Biopsy
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Breast Neoplasms / drug therapy
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Breast Neoplasms / enzymology
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Breast Neoplasms / pathology*
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Female
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Humans
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Immunohistochemistry
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Middle Aged
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Predictive Value of Tests
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Protein Kinase C / metabolism*
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Protein Kinase C-alpha
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Recurrence
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Retrospective Studies
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Tamoxifen / therapeutic use*
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Treatment Failure
Substances
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Antineoplastic Agents, Hormonal
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Tamoxifen
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PRKCA protein, human
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Protein Kinase C
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Protein Kinase C-alpha