Abstract
E1AF is a transcription factor involved in regulation of several metastasis-associated genes, and is associated with overexpression of HER2/neu. We were unable to find a clear prognostic value of E1AF expression in human breast cancer. Furthermore, no association of E1AF levels with HER2/neu mRNA levels, hormone receptor status, histological grade, tumor size, or lymph node involvement was found.
MeSH terms
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Adenovirus E1A Proteins / metabolism*
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Adult
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Aged
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Breast Neoplasms / diagnosis
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Breast Neoplasms / metabolism*
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Carcinoma / diagnosis
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Carcinoma / metabolism*
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Carcinoma / secondary
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Humans
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Lymphatic Metastasis
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Middle Aged
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Prognosis
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Proto-Oncogene Proteins / metabolism*
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Proto-Oncogene Proteins c-ets
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Receptor, ErbB-2 / metabolism
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Receptor, ErbB-3 / metabolism
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Receptors, Steroid / metabolism
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Retrospective Studies
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Transcription Factors / metabolism*
Substances
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Adenovirus E1A Proteins
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ETV4 protein, human
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Proto-Oncogene Proteins
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Proto-Oncogene Proteins c-ets
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Receptors, Steroid
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Transcription Factors
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Receptor, ErbB-2
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Receptor, ErbB-3