Abstract
We performed a case-control study to evaluate the association between antibiotic use and Clostridium difficile-associated diarrhea (CDAD), matching for admission unit and time at risk for CDAD. A multivariable regression model showed that treatment with fluoroquinolones (odds ratio 12.7; 95% confidence interval 2.6 to 61.6) was the strongest risk factor for CDAD.
MeSH terms
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Aged
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Case-Control Studies
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Clostridioides difficile* / isolation & purification
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Clostridium Infections / diagnosis
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Clostridium Infections / epidemiology
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Clostridium Infections / etiology*
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Cross Infection / epidemiology
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Diarrhea / diagnosis
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Diarrhea / epidemiology
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Diarrhea / etiology
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Diarrhea / microbiology*
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Female
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Fluoroquinolones / adverse effects*
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Fluoroquinolones / pharmacology
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Humans
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Male
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Middle Aged
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Odds Ratio
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Risk Factors