Vaccine research efforts for filoviruses

Int J Parasitol. 2003 May;33(5-6):583-95. doi: 10.1016/s0020-7519(03)00064-x.

Abstract

Ebola and Marburg viruses belong to the family Filoviridae, and cause acute, frequently fatal, haemorrhagic fever in humans and non-human primates. No vaccines are available for human use. This review describes the status of research efforts to develop vaccines for these viruses and to identify the immune mechanisms of protection. The vaccine approaches discussed include DNA-based vaccines, and subunit vaccines vectored by adenovirus, alphavirus replicons, and vaccinia virus.

Publication types

  • Review

MeSH terms

  • Animals
  • Ebolavirus / genetics
  • Ebolavirus / immunology
  • Encephalitis Virus, Venezuelan Equine / immunology
  • Filoviridae / immunology*
  • Filoviridae Infections / immunology
  • Filoviridae Infections / prevention & control*
  • Genome, Viral
  • Hemorrhagic Fever, Ebola / immunology
  • Hemorrhagic Fever, Ebola / prevention & control
  • Humans
  • Immunity / immunology
  • Marburg Virus Disease / immunology
  • Marburgvirus / genetics
  • Marburgvirus / immunology
  • Vaccination / methods
  • Vaccines, DNA / immunology
  • Vaccines, DNA / therapeutic use
  • Vaccinia virus / immunology
  • Viral Proteins / immunology
  • Viral Vaccines / immunology
  • Viral Vaccines / therapeutic use*

Substances

  • Vaccines, DNA
  • Viral Proteins
  • Viral Vaccines