DNA damage in brain cells of mice treated with an oxidized form of apomorphine

Brain Res Mol Brain Res. 2003 May 26;114(1):80-5. doi: 10.1016/s0169-328x(03)00127-x.

Abstract

We investigated whether systemic injection of apomorphine and its oxidation derivative 8-oxo-apomorphine-semiquinone (8-OASQ) could induce DNA damage in mice brain, using the single-cell gel assay. 8-OASQ induced DNA damage in the brains at 1 and 3 h, but not at 24 h after treatment whereas apomorphine induced a slight increase in brain DNA damage frequency at 3 h after treatment, suggesting that both drugs display genotoxic activity in brain tissue.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apomorphine / analogs & derivatives
  • Apomorphine / toxicity*
  • Brain / drug effects
  • Comet Assay
  • DNA Damage*
  • Dopamine Agonists / toxicity*
  • Male
  • Mice
  • Mice, Inbred Strains
  • Oxidation-Reduction
  • Oxidative Stress / drug effects
  • Quinones / toxicity*

Substances

  • 8-oxo-apomorphine-semiquinone
  • Dopamine Agonists
  • Quinones
  • Apomorphine